Coen M. Adema

M.Sc. (1987) University of Amsterdam (UVA)
Ph.D. (1992) Free University Amsterdam (VUA)

Professor, University of New Mexico (UNM)

CETI, Department of Biology MSC03 2020,
2428 Castetter Hall
University of New Mexico, Albuquerque, 87131 NM USA
Tel (505) 277 2743 (o); Fax (505) 277 0304,

coenadem@unm.edu

Member of the Biomphalaria glabrata genome initiative

Biomphalaria intitiative logo

Member of the Center for Evolutionary and Theoretical Immunology (CETI)

cobre ceti logo

The Adema Lab


Research interests
Comparative immunobiology, molecular aspects and cell biology of parasite/invertebrate host compatibility, digenean/snail interactions, genomics of molluscs.

Current focus
Molecular characterization of gene expression profiles during anti-pathogen responses of Biomphalaria glabrata; Function, diversity, expression of fibrinogen-related proteins (FREPs) produced by Biomphalaria glabrata and other molluscs, Biomphalaria glabrata genome annotation, Onchocerca lupi in NM, Comparative immunogenomics of Panpulmonata.

TECHNIQUES USED
Parasitology: in vitro culture of Trichomonas vaginalis (flagellate protozoan), maintenance of life cycles and in vitro culture of Acantocheilonema (previously Dipetalonema) viteae (filarial nematode), Trichobilharzia ocellata, Echinostoma paraensei, and Schistosoma mansoni (digenetic trematodes), maintenance of several snail species. Field collection of aquatic snails, testing for digenean infection, Field collection of bloodfeeding arthropods.
Histology: cryostat and parrafin sections
Cell biology: monolayers, phagocytosis, cytochemical assays for lysozymal enzymes, antibody- and lectin-recognized surface epitopes, intravacuole pH and ROIs, spectrophotometrical assays for ROIs, luminol dependent chemiluminescence (LDCL), inhibition of  NADPH-oxidase, development of anti-clumping buffer, density gradient cell separations, cell free ROI cytotoxicity assays, time-lapse video microscopy, confocal microscopy, hemocyte rounding assays, hemocyte bactericidal assay.
Serology: immuno-absorption, immunizations, for antisera and monoclonal antibody production, ELISA, IFAT, western blotting.
Protein biochemistry: size exclusion chromatography, SDS- and native PAGE, blotting, preparation of samples for amino acid sequencing,  protein biotinylation, , proteomics (sample preparation for MS/tandem MS and computational analysis).
Molecular biology: (CTAB) genomic DNA extractions, high molecular weight DNA extraction, alkaline lysis (and kit) plasmid DNA extractions, restriction digests,  (m)RNA extractions, DNA and RNA gel electrophoresis, isotope/biotin labeling of DNA and anti-sense RNA probes, Southern blotting, northern blotting, in-situ hybridization, PCR primer design, PCR, LD-PCR, RT-PCR, qPCR, (TA-) cloning, construction of genomic and cDNA libraries, cycle sequencing, EST-techniques (EST; ORESTES; SSH-ESTs), marathon and gene walker protocols, EZ::TN mediated sequencing of constructs, BAC DNA extraction, subcloning and sequencing, oligo microarray design and probing.
Software: (pc-based) dnasis, chromas, blast, entrez, expasy motifs, image analysis, sequencher, genedoc, bioedit, RNAviz, Newbler, Genespring, Artemis, WebApollo, Galaxy, Mitobim, Mitos.



Curriculum Vitae Coenraad (Coen) Martinus Adema

BIRTH

  27th July 1963, San Jose, California, USA
  USA and Dutch (dual) nationalities

EDUCATION

1984 BS Medical Biology
  University of Amsterdam (UVA), The Netherlands

1987 MS Medical Biology, Cum Laude
  University of Amsterdam (UVA), The Netherlands
  Medical Parasitology: Demonstration of circulating antigens in filariasis.
    subsidiaries
    a) Molecular Cell Pathology: The cloning of single copy DNA from human chromosome 14.
    b) Teaching Degree, general biology.

1992 PhD
 Free University (VU) Amsterdam, The Netherlands
 Dept. of Medical Microbiology and Parasitology,
 Faculty of Medicine, Feb 1988 - July 1992
 Dissertation: Haemocyte-mediated cytotoxicity in the pond snail Lymnaea stagnalis,
 intermediate host of Trichobilharzia ocellata

 POSITIONS

Department of Biology, University of New Mexico (UNM)
Post-doc (Biology, UNM) with Dr ES Loker(1993-1999)
Research Assistant Professor (1997-2003)
Research Associate Professor  (2003-2009)
Associate Professor
(2010-2012)
Associate Professor tenured (2012-2017
)
Associate Director CETI-CEC Controlled Environment Core (2012-)
Professor (2107-)

GRANTS

Dutch Foundation for Scientific Research (NWO) Three week working visit to URPIGM/IFREMER,
  La Tremblade, France. Subject: Comparative gastropod/bivalve immunobiology Feb-Mar 1991

European Community (EC)Human Resources Program personal application for a 2 year post-doc position
  with IFREMER, Montpellier, France. Subject: Bactericidal activity in the bivalve Mytilus edulis
  Post-doc mentor Dr P Roch  Grant was declined as it was awarded only after CM Adema had accepted
  a post-doc position at UNM, Albuquerque, NM, USA  1993

National Science Foundation (NSF) MCB 9974930, Principal investigator (PI)
  Biology UNM, Albuquerque, NM, USA. Subject: Function and diversity of molluscan FREPs
  1 August 1999-2002.

National Science Foundation (NSF) supplement for MCB 9974930, Research experience for undergraduate (REU),
  10 weeks student stipend, summer 2000
.

National Institutes of Health (NIH), NIAID RO1 AI052363, Principal investigator (PI)
 Biology UNM, Albuquerque, NM, USA.  Subject: Anti-pathogen-responses in Biomphalaria glabrata
 April 2003-2011.

University of Wyoming/National Park Service (UW/NPS), Co-principal investigator (co-PI) with Dr RS Seville (UW Casper),
UW/NPS Research Station, Jackson WY, USA. Subject: Parasite infection status of Potamopyrgus antipodarum
July-August 2005.

National Institutes of Health (NIH), NIAID RO1 AI024340, Co-Principal investigator (PI: Dr ES Loker)
Biology UNM, Albuquerque, NM, USA. Subject: Biology of trematode-snail associations
March 2006-2009.

IdEA NCRR, P20RR018754, COBRE Center for Theoretical and Evolutionary Immunology (PI: Dr ES Loker)
Biology UNM (5 year grant). Adema is leader of subproject entitled: Schistosomiasis in snails; basis for long term production of cercariae.
2009-2012.

Research Allocation Committee (RAC), Small Grant Award, Principal investigator (PI),
Biology UNM, Albuquerque, NM, USA. Subject: Canid ocular filariaisis in NM.
January 2013 – July 2014.

The Bill & Melinda Gates Foundation, Grand Challenges Exploration, New Approaches for Detection, Treatment, and Control of Selected Neglected Tropical Diseases
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA. Subject: Sentinel System for Detection of Schistosome Transmission.
November 2013 - May 2015

CETI Waiver for NextGen Sequencing
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA
Subject Genomic sequencing of two species of land snails
May 2015, direct.

CETI Waiver for NextGen Sequencing
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA
Subject Transcriptomic profiling of lab and field isolates of Physella acuta
Dec 2015, direct.

Teaching Allocation Grant (TAG), Teaching Allocations Subcommittee UNM
Primary Instructor, Biology UNM, Albuquerque, NM, USA
Subject: Genome sequencing in a lecture/lab class, hands-on training in modern Next Generation Sequencing and computational bioinformatics
Fall 2016, $1,000.—5.

TEACHING AT UNM (University of New Mexico)

Courses taught
  Introductory Parasitology, 1997
  Comparative Immunology, 1997
  Molecular Cell Biology 2 (426/526) 2002
  Laboratory Methods in Molecular Biology (446/546) Fall 2006,2008,2009,2012,2013,2014,2015,2016
  Parasitology(482L/582L) 2007S, 2009S, 2011S, 2014S
  Molecular and Cell Biology (201) 2007F, 2008S, 2010S, 2012S, 2013S, 2015S, 2016S
  Invertebrate Immunology (401) 2017S
  Invertebrate Immunoparasitology (402/502), 2011F, 2012SF, 2013SF, 2014SF, 2015SF, 2016SF, 2017S

Graduate Students
  Ms student Journey Nolan, Biology UNM, 2011-2013 “Molecular Characterization of the snail Physella acuta” .
  PhD student Janeth J Pena, Biology UNM, 2011-
  PhD student Jonathan Schultz, Biology UNM, 2013-

  PhD student Erin Watson, Biology UNM, 2015-

Graduate Student Committees
PhD students
  Pascale Leonard, Advisor Loker, Biology UNM, 1999-2001
  Shibin Qui, Advisor Lane, Computer Science UNM, 2005-2006
  Kiran Ambatipudi, Advisor Deane, Macquarie University, Sydney, Australia, 2007
  Ramesh Devkota, Advisor Loker, Biology UNM, 2009-2015
  Xin-Xin Wang, Advisor Miller, Biology UNM, 2010-2011
  TyAnne Lovato, Advisor Cripps, Biology UNM, 2011-2014
  Arinder Arora, Advisor Loker, Biology UNM, 2011-2015
  Mattias Roth, Advisor Nair, Macquarie University, Sydney, Australia, 2012
  Li-Jun Lu, Advisor Loker, Biology UNM, 2012-
  Ali Sepahi, Advisor Salinas, Biology UNM, 2013-


Ms students
  Andrew Lynch, Advisor Duszynski, Biology UNM, 2003-2004,
  Noorus Sahar Abubucker, Advisor Lane, Computer Science UNM, 2004-2005
  Michelle Archuleta, Advisor Cunningham, UNM Biology 2007-2008
  Jason Marquardt, Advisor Bergthorsson, UNM Biology 2010-2012

Mentor of Post-baccalaureate Research and Education Program (PREP) scholar
  Journey Nolan, Biology, UNM, 2010-2011. The mitochondrial genome of Physella acuta
  Daniela Martinez, Biology, UNM, 2014-2015 Arthropod vectors of avian malaria within Albuquerque

Supervision of Research Experience for Undergraduates (REU) students
  Biology, University of New Mexico (UNM), NM USA 1993-present
  Sponsors: Howard Hughes Foundation and
  Minority Biomedical Research Support (MBRS), 1993-1998, 2002-2004
  National Science Foundation (REU), Jaime Reif, 2000-2001
  Minority Access to Research careers (MARC), Steven Saenz, Gene discovery in Biomphalaria glabrata, 2004-2005
  Initiative for Minority Student Development (IMSD), Teresa Madrid, FREP BAC sequencing, 2005-2006
  Alliance for Minority Participation (AMP), Bria Riggens, FCM Hemogram of Biomphalaria glabrata , 2013
  Initiative for Minority Student Development (IMSD), Quan M. Huynh, Arthropod vectors of parasites in city parks of Albuquerque NM, 2014-16

Undergraduate Problems 499/student volunteers,
 Fall 2007, Tara Kraus and Casey Smith, Parasite infections of the Red Shiner (Cyprinella lutrensis) in the Rio Grande
 Spring and Fall 2009,Devaraj Aran, Hagit Salomon, Amanda Watson (undergraduate volunteers), Sequencing of the mitochondrial genome of Echinostoma paraensei
 Spring 2011, Zachary Weiss, Estivation in Biomphalaria glabrata
 
Fall 2011, Nathan Romero, Localizing genomic diversification in Biomphalaria glabrata
 
Spring 2012, Thomas Valerio, Bioinformatics analysis of transcriptome of Echinostoma paraensei
 Fall 2012, Spring 2013, Karen A Davila, Onchocerca lupi, filariasis of canids in New Mexico
 Fall 2012, Niels K Winsor (551), Human Toxoplasmosis
 Spring 2013, Amanda Elizabeth Fingado, Gene expression in Physella acuta
 Spring, Fall 2013, Cristin Jones, Onchocerca lupi, filariasis of canids in New Mexico
 Fall 2013, Audrey Melton, Onchocerca lupi, filariasis of canids in New Mexico
 Spring 2016, Bianca Myers, Hemocyanin-like sequences in snailss
 
Spring 2016, Ian Keller, FREP diversity in Physella acuta in snails
 Summer 2017, Hannah Livesay, Onchocerca lupi, filariasis of canids in New Mexico
 Summer 2017, Zachary Fry, Onchocerca lupi, filariasis of canids in New Mexico

AWARDS AND HONORS

Dutch Society for Parasitology (NVP)
  ~US$ 250, awarded twice, towards attendance and oral presentation
  a) Joint Spring Meeting British, Belgian and Dutch Societies for Parasitology,
  Southampton UK 1989
  b) Spring Meeting British Society for Parasitology, Symposium Molluscs in Parasite
  Life Cycles, Liverpool UK 1991

International Society for Developmental and Comparative Immunology (ISDCI)
  US$ 300 towards attendence and presentation,
  Vth ISDCI conference Portland OR, USA (PhD-student category) July 1991

JE Jurriaanse Foundation, Rotterdam, The Netherlands
  ~US$ 1000 towards completion of PhD dissertation June 1992

Keystone Symposia, US$ 500 for scientific merit of poster (post-doc category)
  Molecular Helminthology conference, Santa Fe NM, USA February 1996

10th Symposium on Schistosomiasis, Invited speaker, Belho Horizonte, Brazil, Sep 2005

President's symposium on Immunity in invertebrate hosts of parasites, American Society of Parasitologists (ASP),
  Invited speaker, Joint Meeting at ICOPA, Glasgow, Scotland, Aug 2006

11th Symposium on Schistosomiasis, Invited speaker, Salvador Bahia, Brazil, Sep 2008

26th ESCPBnew Congress, new European Society for Comparative Physiology and Biochemistry,
Invited speaker for symposium Environmental stimuli and their impact on homeostasis and gene regulation
Innsbruck, Austria, Sep 2009

14th Annual Biomedical and Comparative Immunology Symposium, Invited Plenary speaker, Judge student presentation, Florida International University, Miami FL, March 2012

13th Symposium on Schistosomiasis, Invited speaker, Belho Horizonte, Brazil, Sep 2012

Research group Ecologie et Evolution des Interactions (2EI), Planning visit for collaborative research and Departmental Seminar, Université de Perpignan, CNRS, Perpignan, France, Dec 2012.

Certificate of Reviewing Excellence awarded by Elsevier and the Editors of Journal of Invertebrate Pathology, for contributions as a peer reviewer, selected by the editors in recognition of high quality work. 2013.

SCIENTIFIC SOCIETIES

American Society of Parasitologists (ASP)
International Society for Developmental and Comparative Immunology (ISDCI)
Southwestern Association of Parasitologists (SWAP)



Publications

H-index 30, I-10-index 48 (Google Scholar: Jan 2017)
https://scholar.google.com/citations?user=YXcdRNwAAAAJ&hl=en
https://www.researchgate.net/profile/Coen_Adema
orcid.org/0000-0002-6250-5499

1) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Meuleman EA, Sminia T (1991) Generation of oxygen radicals in hemocytes of the snail Lymnaea stagnalis in relation to the rate of phagocytosis. Developmental and Comparative Immunology 15:17-26.

2) Adema CM, van der Knaap WPW, Sminia T (1991) Molluscan hemocyte-mediated cytotoxicity: the role of reactive oxygen intermediates. Reviews in Aquatic Sciences 4:201-223.

3) Adema CM, Harris RA, van Deutekom-Mulder EC (1992) A comparative-study of hemocytes from 6 different snails: morphology and functional-aspects. Journal of Invertebrate Pathology 59:24-32.

4) Harris RA, Adema CM, van Deutekom-Mulder EC (1992) A comparative-study of hemocytes from 6 different snails : surface staining with lectins and monoclonal-antibodies. Comparative Haematology International 2:30-34.

5) Mohandas A, Adema CM, van der Knaap WPW, Sminia T (1992) The effect of hemolymph extraction on distribution of lysosomal-enzymes in Lymnaea stagnalis hemocytes: a cytochemical study. Comparative Haematology International 2:61-67.

6) van der Knaap WPW, Adema CM, Sminia T (1993) Invertebrate blood-cells : morphological and functional-aspects of the hemocytes in the pond snail Lymnaea stagnalis. Comparative Haematology International 3:20-26.

7) Fryer SE, Adema CM (1993) Manipulation of Biomphalaria glabrata (Say) (gastropoda, planorbidae) hemocytes in-vitro. Journal of Molluscan Studies 59:371-379.

8) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Sminia T (1993) NADPH-oxidase activity : the probable source of reactive oxygen intermediate generation in hemocytes of the gastropod Lymnaea stagnalis. Journal of Leukocyte Biology 54:379-383.

9) Adema CM, Mohandas A, van der Knaap WPW, Sminia T (1994) Separation of Lymnaea stagnalis hemocytes by density gradient centrifugation. Developmental and Comparative Immunology 18:25-31.

10) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Sminia T (1994) Schistosomicidal activities of Lymnaea stagnalis hemocytes: the role of oxygen radicals. Parasitology 109:479-485.

11) Nunez PE, Adema CM, de Jong-Brink M (1994) Modulation of the bacterial clearance activity of hemocytes from the fresh-water mollusk, Lymnaea stagnalis, by the avian schistosome, Trichobilharzia ocellata. Parasitology 109:299-310.

12) Adema CM, Arguello DF, Stricker SA, Loker ES (1994) A time-lapse study of interactions between Echinostoma paraensei intramolluscan larval stages and adherent hemocytes from Biomphalaria glabrata and Helix aspersa. Journal of Parasitology 80:719-727

13) Loker ES, Adema CM (1995) Schistosomes, echinostomes and snails: comparative immunobiology. Parasitology Today, 11:120-124

14) Hanelt B, van Schyndel D, Adema CM, Lewis LA, Loker ES (1996) The phylogenetic position of Rhopalura ophiocomae (orthonectida) based on 18S ribosomal DNA-sequence analysis. Molecular Biology and Evolution, 13:1187-1191

15) Hanelt B, Adema CM, Mansour MH, Loker ES (1997) Detection of Schistosoma mansoni in Biomphalaria using nested PCR. Journal of Parasitology 83:387-394

16) Adema CM, Loker ES (1997) Specificity and immunobiology of larval digenean-snail associations. In Advances in Trematode Biology, Eds Fried B, Graczyk TK, CRC Press, Boca Raton Florida, pp 230-263

17) Adema CM, Hertel LA, Loker ES (1997) Infection with Echinostoma paraensei (Digenea) induces parasite-reactive polypeptides in the hemolymph of the gastropod host Biomphalaria glabrata. In Parasite Effects on Host Physiology and Behavior, Ed Beckage N, Chapman Press New York, pp 77-99

18) Adema CM, Hertel LA, Miller RD, Loker ES (1997) A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection. Proceedings of the National Academy of Sciences USA 94: 8691-8696

19) Adema CM, Hertel LA, Loker ES (1999) Evidence from two planorbid snails of a complex and dedicated response to digenean (echinostome) infection. Parasitology 119:395-404.

20) Adema CM, Léonard PM, DeJong RJ, Day H, Edwards D, Burgett G, Hertel LA, Loker ES (2000) Analysis of messages expressed by Echinostoma paraensei miracidia and sporocysts, obtained by random EST sequencing. Journal of Parasitology 86:60-65.

21) Adema CM, Sapp KK, Hertel LA, Loker ES (2000) Immunobiology of the relationship of echinostomes with invertebrate hosts. In Echinostomes as Experimental Models for Biological Research, Eds Fried B, Graczyk TK, Kluwer Academic Publishers, Dortdrecht, The Netherlands, pp 149-174.

22) Léonard PM, Adema CM, Zhang S-M, Loker ES (2001) Structure of two FREP genes that encode IgSF and fibrinogen domains, with comments on diversity of the FREP gene family in the snail Biomphalaria glabrata. Gene 269:155-165.

23) DeJong RJ, Morgan JAT, Paraense WL, Pointier J-P, Amarista M, Ayeh-Kumi PFK, Babiker A, Barbosa CS, Brémond P, Canese AP, de Souza CP, Dominguez C, File S, Gutierrez A, Incani RN, Kawano T, Kazibwe F, Kpikpi  J, Lwambo NJS, Mimpfoundi R, Njiokou F, Poda JN, Sene M, Velásquez LE, Yong M, Adema CM, Hofkin BV,  Mkoji GM and Loker ES (2001) Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke,  Schistosoma mansoni. Molecular Biology and Evolution 18:2225-2239.

24) Zhang S-M, Léonard PM, Adema CM, Loker ES (2001) Parasite responsive IgSF members in the snail Biomphalaria glabrata: characterization of novel genes with tandemly arranged IgSF domains and a fibrinogen domain. Immunogenetics. 53:684-694.

25) Adema CM (2002) Comparative study of cytoplasmic actin DNA from six species of Planorbidae (Gastropoda: Basommatophora). Journal of Molluscan Studies 68:17-23.

26) Horak P, Kolarova L, Adema CM (2002) Biology of the schistosome genus Trichobilharzia. Advances in Parasitology 52:155-233.

27) Loker ES, Adema CM, Zhang S-M, Kepler TB (2004) Invertebrate immune systems – not homogeneous, not simple, not well understood. Immunological Reviews 198:10-24.

28) Zhang S-M, Adema CM, Kepler TB, Loker ES (2004) Diversification of Ig superfamily genes in an invertebrate. Science 305:251-254.

29) DeJong RJ, Emery A, Adema CM (2004) The mitochondrial genome of Biomphalaria glabrata (Gastropoda: Bassomatophora), intermediate host of Schistosoma mansoni. Journal of Parasitology 90:991-996.

30) Nowak S, Woodards A, Jung Y, Adema CM, Loker (2004) Expressed sequence tags (ESTs) differentially expressed during the internal defense response to Schistosoma mansoni of a resistant strain of Biomphalaria glabrata. Journal of Parasitology 90:1034-1041.

31) Hertel LA, Adema CM, Loker ES (2005) Differential expression of FREP genes in two strains of Biomphalaria glabrata following exposure to the digenetic trematodes Schistosoma mansoni and Echinostoma paraensei. Developmental and Comparative Immunology 29:295-303.

32) Qiu S, Adema CM, Lane T (2005) A computational study of off-target effects of RNA-interference. Nucleic Acids Research 33:1834-1847.

33) Jung Y, Nowak S, Hertel LA, Zhang S-M, Loker ES, Adema CM (2005) Manganese superoxide dismutase from Biomphalaria glabrata. Journal of Invertebrate Pathology 90:59-63.

34) Lieb B, Dimitrova K, Kang HS, Braun S, Gebauer W, Martin A, Hanelt B, Saenz SA, Adema CM, Markl J (2006) Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobin. Proceedings of the National Academy of Sciences USA 103:12011-12016. (Epub 2006 Jul 28). PMID: 16877545 PMCID: PMC1567689

35) Adema CM, Luo M-Z, Hanelt B, Hertel LA, Marshall JJ, Zhang S-M, DeJong RJ, Kim H-R, Kudrna D, Wing RA, Soderlund C, Knight M, Lewis FA, Caldeira RL, Jannotti-Passos LK, Carvalho OS, Loker ES (2006) A BAC library for Biomphalaria glabrata, intermediate snail host of Schistosoma mansoni. Memorias do Instituto Oswaldo Cruz 101:167-177. PMID: 17308766

36) Hanelt B, Lun C-M, Adema, CM (2008) Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails. Journal of Invertebrate Pathology, 99, 192-203. PMID 18590737.

37) Coustau C, Gourbal B, Mitta G, Adema CM. (2008). Echinostomes and snails: exploring complex interactions. Chapter 2 in: The Biology of Echinostomes (Fried B and Toledo R, eds.), New York: Springer. 35-60.

38) Stout BA, Adema CM, Zhang S-M, Loker ES (2009) The biology of FREPs: diversified lectins with fibrinogen-related domains from the freshwater snail Biomphalaria glabrata. In Animal Lectins: A Functional View. Eds: G. Vasta & H. Ahmed. CRC Press Taylor & Francis. pp 475-491.

39) Adema CM, Lun C-M , Hanelt B, Seville RS (2009) Digenean trematode infections of native fresh water snails and invasive Potamopyrgus antipodarum in the Grand Teton National Park/John D Rockefeller Memorial Parkway Area. Journal of Parasitology, 95, 224-227. PMID 18576875.

40) Zhang S-M, Nian H, Wang B, Loker ES, Adema CM (2009) Schistosomin from the snail Biomphalaria glabrata: Expression studies suggest no involvement in trematode-mediated castration. Molecular and Biochemical Parasitology. 165, 79-86. PMID: 19393164

41) Adema CM, Hanington PC, Lun CM, Rosenberg GH, Aragon AD, Stout BA, Lennard-Richard ML, Gross PS, Loker ES (2010) Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes). Molecular Immunology 47, 849-860, Epub ahead of print 2009 Dec 2. doi:10.1016/j.molimm.2009.10.019 PMID: 19962194

42) Hathaway JJ, Adema CM, Stout BA, Mobarak CD, Loker ES (2010) Identification of protein components of egg masses indicates parental investment in immunoprotection of offspring by Biomphalaria glabrata (Gastropoda, Mollusca). Dev Comp Immunol. 34, 425–435. Epub ahead of print 2009 Dec 14. doi:10.1016/j.dci.2009.12.001 PMID: 19995576, PMCID: PMC2813990.

43) Hanington PC, Lun CM, Adema CM, Loker ES (2010) Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei.Int J Parasitol. 40, 819-831. Epub ahead of print 2010 Jan 15. doi:10.1016/j.ijpara.2009.12.005 PMID: 20083115

44) Hanington PC, Forys MA, Dragoo JW, Zhang S-M, Adema CM, Loker ES (2010) A role for a somatically diversified lectin in resistance of an invertebrate to parasite infection. Proceedings of the National Academy of Science USA, 49: 21087-21092, [Epub ahead of print] doi: 10.1073/pnas.1011242107. PMID: 21084634, PMCID:PMC3000291

45) Knight M, Ittiprasert W, Odoemelam EC, Adema CM, Miller A, Raghavana N, Bridger JM (2011) Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni. International Journal for Parasitology 41:61-70. [Epub ahead of print] doi:10.1016/j.ijpara.2010.07.015. PMID: 20849859.

46) Mitta G, Adema CM, Gourbal B, Loker ES, Theron A. (2012) Compatibility polymorphism in snail/schistosome interactions: from field to theory to molecular mechanisms. Developmental and Comparative Immunology 37, 1-8 [Epub ahead of print] PMID: 21945832.

47) Van Horn DJ, Hall JR, Loker ES, Mitchell KR, Mkoji GM, Adema CM, Takacs-Vesbach CD (2012) Complex intestinal bacterial communities in three species of planorbid snails. Journal of Molluscan Studies 78:74-80. published online October 11, 2011 doi:10.1093/mollus/eyr038.

48) Lockyer AE, Emery AM, Kane RA, Walker AJ, Mayer CD, Mitta G, Coustau C, Adema CM, Hanelt B, Rollinson D, Noble LR, Jones CS (2012). Identification of an early differential response to Schistosoma mansoni infection in haemocytes from schistosome-resistant and -susceptible Biomphalaria glabrata strains using cDNA microarrays. PLOS ONE, 7:12, e51101.

49) Adema CM, Bayne CJ, Bridger JM, Knight M, Loker ES, Yoshino TP, Zhang S-M. (2012) Editorial Will all scientists working on snails and the diseases they transmit please stand up? PLOS-Neglected Tropical Diseases, 6:12, e1835.

50) Fneich S, Dheilly N, Adema CM, Rognon A, Reichelt M, Bulla J, Grunau C, Cosseau C (2013) 5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni. Parasites & Vectors 06/2013; 6(1):167

51) Kraus TJ, Brant SV, Adema CM (2014) Characterization of trematode cercariae from Physella acuta in the Middle Rio Grande. Comparative Parasitology, Comparative Parasitology, 81(1),105–109. doi: http://dx.doi.org/10.1654/4674.1.

52) Dheilly N, Adema CM, Raftos DA, Grunau C, Du Pasquier L (2014) No more non-model species: the promise of next generation sequencing for comparative immunology. Developmental and Comparative Immunology. 45:56-66. doi: 10.1016/j.dci.2014.01.022. PMID: 24508980

53) Nolan JR, Bergthorsson U, Adema CM (2014) Physella acuta: atypical gene order among mitochondrial genomes of Panpulmonata. Journal of Molluscan Studies, doi:10.1093/mollus/eyu025. PMID: 25368439

54) Dheilly NM, Duval D, Mouahid G, Emans R, Allienne J-F, Galinier R, Genthon C, Dubois E, Du Pasquier L, Adema CM, Grunau C, Mitta G, Gourbal B (2015) A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata . Developmental and Comparative Immunology. 48:234–243. doi.org/10.1016/j.dci.2014.10.009. PMID: 25451302

55) Adema CM, Loker ES (2015) Digenean-gastropod host associations reveal foundations of specific immunity in snails. Developmental and Comparative Immunology, 48 pp. 275-283: doi:10.1016/j.dci.2014.06.014. PMID: 25034871.

56) Coustau C, Gourbal B, Duval D, Yoshino TP, Adema CM, Mitta G (2015) Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade. Fish and Shellfish Immunology 46, 5-16. doi: 10.1016/j.fsi.2015.01.036. PMID: 25662712.

57) Zhang S-M, Buddenborg SK, Adema CM, Sullivan JT, Loker ES (2015) Altered gene expression in the schistosome-transmitting snail Biomphalaria glabrata following exposure to niclosamide, the active ingredient in the widely used molluscicide Bayluscide. PLOS-Neglected Tropical Diseases. doi:10.1371/journal.pntd.0004131 PMID:26452273, PMC4599737

58) Adema CM (2015) Fibrinogen-related proteins (FREPs) in mollusks. Chapter 6 Pathogen-Host Interactions: antigenic variation v. somatic adaptations. (Hsu E and DuPasquier L, eds), New York: Springer. 111-130. doi: 10.1007/978-3-319-20819-0. PMID:265373797

59) McLean N, Newkirk K, Adema CM (2016) Canine ocular onchocerciasis: a retrospective review of the diagnosis, treatment and outcome of 16 cases in New Mexico (2011-2015). Veterinary Ophthalmology doi: 10.1111/vop.12433. PMID:27624855.

60) Pena JJ, Adema CM (2016) The planorbid snail Biomphalaria glabrata expresses a hemocyanin-like sequence in the albumen gland. PLoS ONE 11(12): e0168665. doi:10.1371/journal.pone.0168665. PMID: 28036345.

61) Schultz JH, Adema CM (2017) Comparative immunogenomics of molluscs. Developmental and Comparative Immunology. doi:10.1016/j.dci.2017.03.013

62) Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira , Raghavan N, Shedlock A, Amaral LR do, Arican-Goktas HD, Assis J, Baba EH, Baron OL, Bayne CJ, Bickham-Wright U, Biggar KK, Blouin M, Bonning BC, Botka C, Bridger JM, Buckley KM, Buddenborg SK, Caldeira RL, Carleton J, Carvalho OS, Castillo MG, Chalmers IW, Christensens M, Clifton S, Cosseau C, Coustau C, Cripps RM, Cuesta-Astroz Y, Cummins S, diStephano L, Dinguirard N, Duval D, Emrich S, Feschotte C, Feyereisen R, FitzGerald P, Fronick C, Fulton L, Galinier R, Geusz M, Geyer KK, Giraldo-Calderon G, Gomes de Souza M, Gordy MA, Gourbal B, Grossi S, Grunau C, Hanington PC, Hoffmann KF, Hughes D, Humphries J, Izinara R, Jackson DJ, Jannotti-Passos LK, Jeremias de Jesus W, Jobling S, Kamel B, Kapusta A, Kaur S, Koene JM, Kohn AB, Lawson D, Lawton SP, Liang D, Limpanont Y, Lockyer AE, Lovato TL, Liu S, Magrini V, McManus DP, Medina M, Misra M, Mitta G, Mkoji GM, Montague MJ, Montelongo C, Moroz LL, Munoz-Torres MC, Niazi U, Noble LR, Pais F, Papenfuss AT, Peace R, Pena JJ: Pila EA, Quelais T, Raney BJ, Rast JP, Ribeiro F, Rollinson D, Rotgans B, Routledge EJ, Ryan KM, Scholte L, Silva F, Storey KB, Swain M, Tennessen JA, Tomlinson C, Trujillo DL, Volpi EV, Walker AJ, Wang T, Wannaporn I, Warren WC, Wu X-J, Yoshino TP, Yusuf M, Zhang S-M, Zhao M, Wilson R (2017) Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8, 15451 doi: 10.1038/ncomms15451.

Miscellaneous

 1) Adema CM, Knight M, Lewis FA, Loker ES (2002) Request for making a BAC library from Biomphalaria glabrata (gastropod mollusc), the prominent snail species contributing to transmission of human schistosomiasis. In July 2002, review of this white paper by the Genome Resources and Sequencing Priorities Panel (GRASPP) of the NHGRI (National Human Genome Research Institute) BAC Resource Steering Panel yielded a "high priority" recommendation. In cooperation with the NIH BAC resources program, a BAC library was produced that is now available to the research community.

2) Knight M, Adema CM, Raghavan N, Loker ES, Lewis FA, Tettelin H (2003) Obtaining the genome sequence of the mollusc Biomphalaria glabrata: a major intermediate host for the parasite causing human schistosomiasis. In July 2004, review of this white paper resulted in the addition of B. glabrata to the genome sequencing pipeline of NHGRI ("high priority" recommendation)


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