STATIONARY-PHASE IN SACCHAROMYCES-CEREVISIAE
WERNERWASHBURNE M, BRAUN
EL, CRAWFORD ME, PECK VM
MOLECULAR MICROBIOLOGY
v. 19(#6) pp. 1159-1166 1996
- Institutions:
- UNIV NEW MEXICO,DEPT BIOL/ALBUQUERQUE//NM/87131
- Abstract:
- Like other microorganisms, the yeast Saccharomyces cerevisiae
responds to starvation by arresting growth and entering stationary
phase, Because most microorganisms exist under conditions of
nutrient limitation, the ability to tolerate starvation is
critical for survival. Molecular analyses have identified changes
in transcription, translation, and protein modification in
stationary-phase cells. At the level of translation, the pattern
of newly synthesized proteins in stationary-phase cells is
surprisingly similar to the pattern of proteins synthesized during
exponential growth, When limited for different nutrients, yeast
strains may not enter stationary phase but opt for pathways such
as pseudohyphal growth. If nutrient limitation continues, the
end-point is likely to be a stationary-phase cell, Based on the
results of recent studies, we propose a model for entry into
stationary phase in which G(0) arrest is separable from
acquisition of the ability to survive long periods of time without
added nutrients.
- Keywords:
- DEPENDENT PROTEIN-KINASE; MITOTIC CELL-CYCLE; RNA
POLYMERASE-II; HEAT-SHOCK; PHYSIOLOGICAL STATUS; POLYUBIQUITIN
GENE; REGULATORY SUBUNIT; YEAST-CELLS; LIFE-CYCLE; GROWTH
- Categories:
- BIOCHEMISTRY & MOLECULAR BIOLOGY; MICROBIOLOGY