Biol 444/544 Spring '01

Books:

For non-biology majors: Essential Cell Biology; Alberts, Bray, et al.; Garland Press (look under Bio219 in the bookstore).

Online Biology text: Kimball's Biology Pages

Pittsburgh Super Computer: Life sciences text - genomics issues

 

For biology majors: ......Online Lectures in Bioinformatics- Germany

UNIX help (Staben, Kentucky)

(other bioinformatics links)

 

Journals

GenomeBiology

Other Suggested References:

An Introduction to the Genetics and Molecular Biology of the Yeast Saccharomyces cerevisiae. Fred Sherman 

 

Links to Papers for week 1:

 

GENOMICS:Journey to the Center of Biology; Eric S. Lander and Robert A. Weinberg; Science Magazine

Genomics: what is realistically achievable? Ross Overbeek Genome Research

Whither genomics? Andrew W Murray Genome Research

Gene prediction: the end of the beginning Colin Semple

Tutorial - Bases and spaces: resources on the web for accessing the draft human genome Colin Semple

 

Papers for sequence assembly:

Gordon, D., Abajian, C. and Green, P. (1998) Consed; a graphical tool for sequence finishing. Genome Researh, 8, 195-202.

Ewing, B., Hillier, L., Wendl, M.C. and Green, P. (1998) Base-calling of automated sequencer traces using Phred. I. Accuracy assessment. Genome Research, 8, 175-185.

Ewing, B. and Green, P. (1998) Base-calling of automated sequencer traces using Phred. II. Error probabilities. Genome Research, 8, 186-194.

Microarray papers:

Holstege, F.C.P., Jennings, E.G., Wyrick, J.J., Lee, T.I., Hengartner, C.J., Green, M.R., Golub, T.R., Lander, E.S. and Young, R.A. (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95, 717-728.

Spellman, P. T., G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein, and B. Futcher. 1998. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Molecular Biology of the Cell 9(#12):3273-3297.

Hughes, T., M. Marton, A. Jones, C. Roberts, R. Stoughton, C. Armour, H. Bennett, E. Coffey, H. Dai, Y. He, M. Kidd, A. King, M. Meyer, D. Slade, P. Lum, S. Stepaniants, D. Shoemaker, D. Gachotte, K. Chakraburtty, J. Simon, M. Bard, and S. Friend. 2000. Functional discovery via a compendium of expression profiles. Cell 102:109-126. PPT

 

Clustering papers:

Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Trevor Hastie1, 2, Robert Tibshirani2, 1, Michael B Eisen3, Ash Alizadeh4, Ronald Levy5, Louis Staudt6, Wing C Chan7, David Botstein8, Patrick Brown4. 2000 Genome Biology

Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci 95:14863-14868.

Aach, J., W. Rindone, and G. Church. 2000. Systematic management and analysis of yeast gene expression data. Genome Research 10:431-445.

Sherlock, G. 2000. Analysis of large-scale gene expression data. Current Opinion in Immunology 12(#2):201-205.

 

Selection of genome sequencing papers:

Fleischmann, R.D., Adams, M.D., White, O., Clayton, R.A., Kirkness, E.F., Kerlavage, A.R., Bult, C.J., Tomb, J.F., Dougherty, B.A. and Merrick, J.M. (1995) Whole-genome random sequencing and assembly of Heamophilus-influenzae RD. Science, 269, 496-512.

Ainscough, R. and al., e. (1998) Genome sequence of the nematode C-elegans: A platform for investigating biology. Science, 282, 2012-2018.

Anderson, S., Zomorodipour, A., Anderson, J., Sicheritz-Ponten, T., Alsmark, U., Podowski, R., Naslund, A., Erikson, A., Winkler, H. and Kurland, C. (1998) The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature, 396, 133-140.

Bult, C. and al, e. (1996) Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science, 273, 1058-1073.

Fraser, C.M. and al., e. (1995) The minimal gene complement of Mycoplasma genitalium. Science, 270, 397-403.

Goffeau, A., Barrell, B.G., Bussey, H., Davis, R.W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J.D., Jacq, C., Johnston, M., Louis, E.J., Mewes, H.W., Murakami, Y., Philippsen, P., Tettelin, H. and Oliver, S.G. (1996) Life with 6000 genes. Science, 274, 546-567.

 Evolution and horizontal gene transfer:

Doolittle, W.F. (1999) Lateral genomics. Trends in Biochemical Sciences, 24, M5-M8.

Phylogenetic classification of proteins encoded in complete genomes. Clusters of Orthologous Groups

Proteomics:

Dutt, M.J. and Lee, K.H. (2000) Proteomic analysis. Current Opinion in Biotechnology, 11, 176-179.

 Other:

A cultivated taste for yeast . Charles Brenner Genome Research

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