People

William Hlavacek, PhD
Technical Staff Member, Theoretical Division,
Los Alamos National Laboratory

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Research interests

• Signal transduction in the immune system
• Biophysical models of ligand-receptor binding
• HIV dynamics
• Design principles of genetic regulatory systems
• Metabolomics and modeling of metabolic networks

William S. Hlavacek received his Ph.D. in chemical engineering from University of Michigan.  He did postdoctoral work at Los Alamos National Laboratory, where he is now a Technical Staff Member in the Theoretical Biology and Biophysics Group.  He is also Adjunct Assistant Professor in the Department of Biology at the University of New Mexico.  He has worked on bacterial gene regulation, multivalent ligand-receptor binding, HIV dynamics, and eukaryotic signal transduction.  He is interested in mathematical modeling of complex dynamic systems that are important in microbiology and immunology.  His CETI project is aimed at mathematical modeling of membrane-proximal events in signal transduction by a TIR receptor, the interleukin-1 (IL-1) receptor type 1 (IL-1R1).  This receptor plays an important role in inflammation and is closely related to Toll-like receptors (TLRs), pathogen-recognition receptors of the innate immune system.  More information about this project is available at cellsignaling.lanl.gov

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